Heungsup Sung,1 Sang-Moo Kang,2 Moo-Song Lee,3 Tai Gyu Kim,4 and Young-Keol Cho1*
Department of Microbiology1 and Preventive Medicine,3 University of Ulsan College of Medicine, Seoul 138-040,
Korea, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School
of Medicine, Atlanta, Georgia 30322,2 and Department of Microbiology, College of Medicine,
The Catholic University of Korea, Seoul 137-701, Korea4
Received 27 December 2004/Returned for modification 13 January 2005/Accepted 7 February 2005
Long-term intake of Korean red ginseng (KRG) delayed disease progression in human immunodeficency virus type 1-infected patients. Additionally, KRG intake significantly slowed the decrease in CD4 T cells even when influence of HLA class I was statistically eliminated. Researchers also observed significant correlation between KRG intake and a decrease in serum soluble CD8 antigen level. These data show that KRG intake independently and significantly affected the slow depletion of CD4 T cells irrespective of HLA class I. Korean Ginseng not only maintained CD4 T-cell counts in HIV patients over a 6 year period, but also reduced viral resistance to AZT.
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CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, Apr. 2005, p. 497–501 Vol. 12, No. 4
Copyright © 2005, American Society for Microbiology. All