Study Suggests Nutritional Formula Can Decrease ART-Naive Patient's Average CD4 Cell Loss

BITE Study results of the nutritional supplement NR100157 presented recently at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2009) in San Francisco suggests that many treatment-naive HIV+ individuals can slow their CD4 cell loss by taking a daily nutritional supplement. Participants in the study were randomly selected and divided into a control group and a group designated to take the nutritional supplement. Those participants taking the nutritional supplement lost an average of fewer than half of the CD4 cells than did their peers in the control arm of the study. The average yearly CD4 cell loss for participants in the nutritional supplement arm of the study was 28 CD4 cells vs 68 CD4 cells in the control group not taking supplementation. The viral load of participants in both arms of the study remained stable.
The 340 study participants were 80 per cent male with an average age of 40 years. They had tested HIV+ an average of 420 days prior to beginning the study and had an average of 420 CD4 cells with an average viral load of approximately 32,000 copies.
Researchers composed the NR100157 compound of singular ingredients that had previously shown an immune benefit when studied alone. NR100157 contains vitamins and minerals, bovine colostrum, omega-3 fatty acids, N-acetyle cysteine, and prebiotic oligosaccharides. The individual ingredients are aimed at reducing oxidative stress on the body, enhancing nutrient absorption in the body, and maintaining digestive tract integrity. Further studies are needed but the NR100157 study could lead to longer, healthier lives for HIV+ individuals, potentially reduce the high lifetime expenditures for anti-HIV medications, and possibly delay treatment initiation.

HIV and Hepatitis.com Coverage of the
49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2009)

Form of Selenium Shows Promise in Reducing HIV Viral Load By 10-Fold

Researchers at Penn State have reported a form of the anti-oxidant mineral Selenium proves to reduce HIV viral load in vitro by 10-fold. Sodium Selenite was used in test tubes to prevent HIV from reproduce in human blood. Healthy volunteers donated blood. Later the blood was infected with HIV and small amounts of sodium selenite were added. Viral replication was reduced by 10-fold. Selective reduction of the selenium compound in the cells increased viral replication by 3.5 per cent. This suggests that incorporating a selenium compound into current HIV therapies could prove a valuable method of complementary anti-viral therapy.

Science Daily

Oral Health Linked to HIV Disease Progession

Japanese researchers at the Tokyo-based Nihon University have discovered that an acid produced in gum disease seems to accelerate the Human Immuno-deficiency Virus. Certain bacteria in periodontal or gum disease create a distinctively smelly substance called butyric acid. Butyric acid in turn inhibits an enzyme called HDAC that prevents HIV from reproducing. While not everyone with HIV gets periodontal disease, certain people are constitutionally prone to the disease. The study suggests that health-care workers should actively encourage all of their HIV+ patients to aggressively pursue their oral health habits including regular dental check-ups, daily brushing, and especially daily flossing to remove food debris that can promote the production of bacteria that produce the butyric acid. Butyric acid has an odor that has been likened to socks worn for several days or rancid butter.

Agence France-Presse(AFP)

Mindfulness Meditation Slows Decline of CD4 T cells in HIV Patients

Researchers at the University of California have demonstrated that the practice of Mindfulness Meditation shows promise in halting the decline of CD4 T cell counts in HIV+ patients. Mindfulness Meditation is a meditation technique that encompasses breathing techniques and being present in the present moment in time. Thoughts of the past or future are not welcome in this technique because the practitioner tends to experience increased stress levels when dwelling on the past experiences or future pressures or plans. The technique is specifically designed to decrease stress levels. Study results over 8 weeks showed that HIV+ patients received beneficial results whether they were actively taking anti-retroviral medications or not during the study duration. The study also concluded that patient's response increased as they increased the time they spent practicing Mindfulness Meditation. Control patients (those not practicing Mindfulness Meditation whether taking medication or not) showed decreases in their CD4 T cells over the study duration. This suggests that stress plays a significant role in progression of HIV disease.

ScienceDaily

University of California, Los Angeles. "Mindfulness Meditation Slows Progression Of HIV, Study Suggests." ScienceDaily 27 July 2008. 22 February 2009 .